Critical Point Drying: Precision Sample Preparation for Nanoscale Analysis

Sample preparation is a cornerstone of nanotechnology, and the Leica CPD3 Critical Point Dryer ensures delicate structures are preserved for analysis. By eliminating surface tension effects, it enables high-fidelity imaging and fabrication.

The CPD3 uses supercritical CO2 to dry samples, maintaining structures like porous nanomaterials or biological tissues. Its automated controls regulate pressure and temperature, achieving consistent results with minimal operator intervention. Safety features, such as overpressure protection, ensure reliable operation.

In applications, CPD is critical for preparing samples for SEM, preserving features like nanoparticle morphology or cellular ultrastructure. In energy storage, it maintains the integrity of electrode materials, enabling accurate electrochemical testing.

Our services integrate the CPD3 into comprehensive workflows, preparing samples for characterization with AFM or TEM. For a recent project, we used CPD to preserve a hydrogel scaffold, enabling precise mechanical analysis with AFM, achieving a Young’s modulus accuracy of ±5%.

We optimize drying protocols for specific materials, adjusting fluid exchange rates to prevent cracking. Future advancements, like integrated spectroscopy during drying, will further enhance precision. Our expertise ensures samples are prepared to the highest standards, supporting groundbreaking research.